401 As Walt Whitman reminded us, we "contain multitudes" and are never the same self from moment to moment, much less year to year. Yet we seem to need a sense of self to feel whole and real. But how much of this vital quality of individual selfhood is an illusion, the accidental side effect of neurophysiological events?cascading sense impressions, vagrant memories, rushes of emotion?all tied up neatly into an apparently single story by our cognitive faculties? In this illuminating panel discussion, a neuropsychiatrist, a teacher of mindfulness, and a science writer/poet will reflect on the meaning and nature of the "self," and give us some sense of how ancient practices of mindfulness meditation and the most recent discoveries in brain science expand and enrich our understanding of the self and its multiplicities.